產(chǎn)品中心
相關(guān)產(chǎn)品
中藥標(biāo)準(zhǔn)品
|
產(chǎn)品編號(hào) |
英文名稱 |
CAS號(hào) |
包裝 |
|
Y3713 |
(S)-(+)-Camptothecin |
7689-03-4 |
可根據(jù)客戶要求訂制 |
產(chǎn)品編號(hào)：Y3713
英文名稱：(S)-(+)-Camptothecin
CAS號(hào)：7689-03-4分析標(biāo)準(zhǔn)品,≥98%
分子式 C20H16N2O4 分子量348.35
基本信息:
密度 1.51
熔點(diǎn) 259-263°C
存貯條件 貯存溫度2-8℃
描述
產(chǎn)品介紹 微溶于乙醇、氯仿，難溶于水。與酸不能生成穩(wěn)定的鹽，與氫氧化鈉溶液加熱反應(yīng)可生成鈉鹽而溶于水。鈉鹽水溶液黃色澄明具藍(lán)色熒光
別名 喜樹(shù)堿 ;4-乙基-4-羥基-1H-吡喃[3'，4'：6，7]氮茚[1，2]喹啉-3，14(4H，12H)-二酮;4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
生化機(jī)理
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.
應(yīng)用 不可逆轉(zhuǎn)地的結(jié)合到DNA拓?fù)洚悩?gòu)酶I復(fù)合物上，影響細(xì)胞周期進(jìn)程
熔點(diǎn) 259-263°C
存貯條件 貯存溫度2-8℃
描述
產(chǎn)品介紹 微溶于乙醇、氯仿，難溶于水。與酸不能生成穩(wěn)定的鹽，與氫氧化鈉溶液加熱反應(yīng)可生成鈉鹽而溶于水。鈉鹽水溶液黃色澄明具藍(lán)色熒光
別名 喜樹(shù)堿 ;4-乙基-4-羥基-1H-吡喃[3'，4'：6，7]氮茚[1，2]喹啉-3，14(4H，12H)-二酮;4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
生化機(jī)理
Camptothecin (CPT), a cytotoxic quinoline alkaloid, is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231. It has recently been undergoing phase I clinical trials. In 3D fluorescence spectra, Camptothecin presented 3 fluorescence peaks with excitation wavelengths lambdaex of 215, 255 and 365 nm, separately. Camptothecin shows high activity against various tumor cells.
應(yīng)用 不可逆轉(zhuǎn)地的結(jié)合到DNA拓?fù)洚悩?gòu)酶I復(fù)合物上，影響細(xì)胞周期進(jìn)程
- 上一條：班蝥素
- 下一條：3-乙酰基-9-羥基巴卡丁III
