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中藥標(biāo)準(zhǔn)品
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產(chǎn)品編號(hào) |
英文名稱 |
CAS號(hào) |
包裝 |
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Y3687 |
6,7-Dimethoxycoumarin |
120-08-1 |
可根據(jù)客戶要求訂制 |
產(chǎn)品編號(hào)：Y3687
英文名稱：6,7-Dimethoxycoumarin
CAS號(hào)：120-08-1分析標(biāo)準(zhǔn)品,≥98%
分子式 C11H10O4 分子量206.19
基本信息:
密度 1.248
熔點(diǎn) 143-145°C
溶解性 Soluble in DMSO (15 mg/ml), and water (partly miscible).
描述
產(chǎn)品介紹 Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
別名 蒿屬香豆素;Scoparone;6,7-Dimethylesculetin;6,7-Dimethoxy-2H-chromen-2-one;6,7-Dimethoxy-2-benzopyrone
應(yīng)用 An agent that can up-regulate the expression and activate CAR
