英文名稱：Picropodophyllotoxin
CAS號(hào)：477-47-4
分析標(biāo)準(zhǔn)品,≥98%
分子式 C22H22O8 分子量414.41

基本信息:

密度1.37
存貯條件 貯存溫度2-8℃
描述
別名 IGF-1R 抑制劑;PPP;(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; NSC 36407; Picropodophyllin; PPP;IGF-1R Inhibitor, PPP;AXL1717
生化機(jī)理
Picropodophyllotoxin (PPP) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Picropodophyllotoxin exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Picropodophyllotoxin inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
應(yīng)用 苦鬼臼毒素是胰島素樣生長(zhǎng)因子-I（IGF-I）受體激酶抑制劑。