產(chǎn)品編號(hào)：Y0049

英文名稱：Mono-2-ethylhexyl Phthalate

CAS號(hào) 4376-20-9

分析標(biāo)準(zhǔn)品

分子式 C16H22O4 分子量278.34

基本信息:

屬性

存貯條件  儲(chǔ)存溫度2-8℃

描述

別名  鄰苯二甲酸單(2-乙基己基)酯;2-Ethylhexyl Hydrogen Phthalate Monooctyl Phthalate Phthalic Acid Mono-2-ethylhexyl Ester Phthalic Acid Monooctyl Ester

生化機(jī)理  MEHP is a bioactive metabolite of DEHP which inhibits the 17,20 lyase activity of CYP17. MEHP has been shown to modulate the expression of a broad spectrum of genes, including the downregulation of the steroidogenic genes Insl3, expressed in Leydig cells, and Inha, expressed in both Leydig and Sertoli cells during fetal life. It has also been shown to induce apoptosis in germ and Sertoli cells via disruption of junction complexes.

應(yīng)用  DEHP的一種具有生物活性的代謝物。